Premium
Gene Targeting Reveals Multiple Essential Functions of the Neuregulin Signaling System during Development of the Neuroendocrine and Nervous Systems
Author(s) -
CRONE STEVEN A.,
LEE KUOFEN
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04525.x
Subject(s) - neuregulin , neuregulin 1 , erbb4 , biology , nervous system , receptor , neuroscience , erbb3 , gene , gene targeting , signal transduction , in vivo , computational biology , bioinformatics , microbiology and biotechnology , genetics , receptor tyrosine kinase
A bstract : Mice harboring targeted mutations in neuregulin‐1 and its receptors ( erbB2 , erbB3 , and erbB4 ) have been invaluable tools for testing the roles of these genes in vivo as well as for identifying unexpected functions for this signaling system. This review summarizes the advances in understanding the myriad functions of neuregulins in the nervous and neuroendocrine systems that have been revealed by examining gene‐targeted mice.