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Catecholaminergic Pathways, Chromaffin Cells, and Human Disease
Author(s) -
PARMER ROBERT J.,
ZINDER OREN
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04514.x
Subject(s) - catecholaminergic , chromaffin cell , disease , biology , neuroscience , pharmacogenetics , function (biology) , adrenal medulla , dopamine , catecholamine , medicine , microbiology and biotechnology , gene , genetics , genotype
A bstract : Recent studies demonstrate major effects of adrenal medullary and catecholaminergic pathways on a wide variety of normal physiologic and regulatory events. Alterations in these pathways, involving changes in catecholamines or in proteins and peptides costored and coreleased with catecholamines, may lead to profound changes in autonomic, cardiovascular, neuroendocrine, metabolic, nociceptive, and immune function. These findings have important implications for a variety of human disease states. In addition, molecules associated with catecholaminergic function may provide novel diagnostic and therapeutic strategies for human disease and suggest specific genetic loci as important and fruitful targets for further genetic and pharmacogenetic studies.