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Fast‐Breaking Results on the PACAP/VIP/Secretin Peptide Family in Chromaffin Cells
Author(s) -
VAUDRY DAVID,
TAUPENOT LAURENT
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04509.x
Subject(s) - secretin , vasoactive intestinal peptide , chromaffin cell , medicine , endocrinology , neuropeptide , chromogranin a , sympathoadrenal system , cell culture , adrenal medulla , biology , catecholamine , chemistry , secretion , receptor , immunohistochemistry , genetics
A bstract : The neuropeptide pituitary adenylyl cyclase‐activating polypeptide (PACAP) has been reported to be a potent regulator of chromaffin cell activity. In particular, PACAP stimulates catecholamine biosynthesis as well as the expression of various genes, including chromogranin A, neuropeptide Y, enkephalins, vasoactive intestinal polypeptide, and PACAP itself. The mechanisms involved in the effects of PACAP on chromaffin cells have been investigated using rat pheochromocytoma PC12 cells. This cell line turned out to be a suitable model in which to study the neurotrophic activities of PACAP. Recent studies using transgenic mice have shown that in the sympathoadrenal system, PACAP acts as an “emergency response” cotransmitter involved in the regulation of insulin‐induced hypoglycemia.