Premium
Inositol 1,4,5‐Trisphosphate Receptor/Ca 2+ Channel Modulatory Role of Chromogranins A and B
Author(s) -
YOO SEUNG HYUN,
SO SEUNG HO,
HUH YANG HOON,
PARK HEE YUN
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04484.x
Subject(s) - inositol , chemistry , intracellular , receptor , biophysics , gene isoform , inositol trisphosphate receptor , secretory vesicle , microbiology and biotechnology , function (biology) , secretory protein , inositol trisphosphate , biochemistry , secretion , biology , exocytosis , gene
A bstract : The secretory granules function as the major IP 3 ‐sensitive intracellular Ca 2+ store of secretory cells. Recently it was found that the secretory granules contain three isoforms of inositol 1,4,5‐trisphosphate receptor (IP 3 R)/Ca 2+ channels and high‐capacity, low‐affinity Ca 2+ storage proteins chromogranins A (CgA) and B (CgB). The IP 3 R/Ca 2+ channel was shown to directly interact with CgA and CgB at the intragranular pH 5.5, and this coupling led to modulation of the IP 3 R/Ca 2+ channel activity by the coupled chromogranins. These results provide the molecular structural basis of the IP 3 ‐mediated Ca 2+ release mechanism of secretory granules.