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Role of CAPS in Dense‐Core Vesicle Exocytosis
Author(s) -
WASSENBERG JAMES J.,
MARTIN THOMAS F.J.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04464.x
Subject(s) - exocytosis , adrenal medulla , munc 18 , enteroendocrine cell , secretion , microbiology and biotechnology , biology , vesicle , endocrine system , endocrinology , pancreatic islets , medicine , islet , catecholamine , hormone , synaptic vesicle , membrane , biochemistry , insulin
A bstract : Calcium‐dependent activator protein for secretion (CAPS) was initially identified in brain cytosol based on its ability to reconstitute calcium‐triggered dense‐core vesicle (DCV) exocytosis in permeable cell lines (PC12) of adrenal chromaffin origin. Current evidence indicates that CAPS functions selectively in DCV exocytosis by interacting with DCVs, the plasma membrane, and protein components of the fusion machinery. To further delineate the role of CAPS in endocrine and neural secretion, the tissue distribution of CAPS was determined. Immunoreactive CAPS I localized exclusively to neural and endocrine tissues including adrenal medulla, pancreatic islets, anterior pituitary, thyroid parafollicular C cells, gastrointestinal G cells, renal juxtaglomerular cells, and gray matter throughout the central nervous system. The results are consistent with a widespread functional role of CAPS in the regulated exocytosis of DCVs in the nervous and endocrine systems.