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Exocytosis: The Chromaffin Cell As a Model System
Author(s) -
BADER MARIEFRANCE,
HOLZ RONALD W.,
KUMAKURA KONOSUKE,
VITALE NICOLAS
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04461.x
Subject(s) - exocytosis , munc 18 , secretion , chromaffin cell , microbiology and biotechnology , vesicle , biology , vesicle fusion , secretory vesicle , chemistry , neuroscience , adrenal medulla , synaptic vesicle , biochemistry , catecholamine , membrane
A bstract : Neurons and neuroendocrine cells release transmitters and hormones by exocytosis of secrctory vesicles or granules. Among the cell models that have provided insight into the molecular machinery underlying the successive steps of exocytosis, adrenal chromaffin cells have taken a prominent place. Thus, most of the molecular players that orchestrate the formation, targeting, docking, and fusion of secrctory granules have been identified in chromaffin cells. By offering the opportunity to combine the use of recent biophysical techniques allowing single‐vesicle resolution and specific biochemical modifications in the protein machinery involved in exocytosis, chromaffn cells remain a powerful model to address new and still open questions in the field of secretion.