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How Does Histamine Evoke Catecholamine Secretion from Bovine Chromaffin Cells?
Author(s) -
MARLEY PHILIP D.,
WALLACE DAMIAN,
DONALD AMANDA,
McKENZIE SACHA
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04451.x
Subject(s) - histamine , secretion , catecholamine , chromaffin cell , endocrinology , depolarization , medicine , chemistry , extracellular , phospholipase c , receptor , adrenal medulla , biology , biochemistry
A bstract : Histamine‐evoked catecholamine secretion from bovine chromaffin cells was studied. Secretion was not prevented by inhibitors of IP3 receptors, protein kinase C, or phospholipase C; depleting Ca 2+ stores; or omitting extracellular Na + or Cl − . Patch clamp studies showed histamine inhibited an M current, causing depolarization and firing of action potentials.