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Effects of Methyllycaconitine and Related Analogues on Bovine Adrenal α3β4* Nicotinic Acetylcholine Receptors
Author(s) -
BRYANT DARRELL L.,
FREE R. BENJAMIN,
THOMASY SARA M.,
LAPINSKY DAVID J.,
ISMAIL K. A.,
ARASON K. M.,
BERGMEIER STEPHEN C.,
McKAY DENNIS B.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04448.x
Subject(s) - methyllycaconitine , nicotinic agonist , acetylcholine receptor , chemistry , receptor , ganglion type nicotinic receptor , acetylcholine , pharmacology , secretion , alpha 4 beta 2 nicotinic receptor , endocrinology , medicine , nicotinic acetylcholine receptor , biology , biochemistry
A bstract : Adrenal secretion and binding studies were performed using ring E analogues of methyllycaconitine to assess structural determinants affecting activity on bovine adrenal α3β4* nicotinic receptors. The most potent analogues are as potent as many inhibitors of adrenal secretion. Our data support the potential use of methyllycaconitine analogues to generate nicotinic receptor subtype‐specific compounds.