Premium
Functional Nicotinic Acetylcholine Receptor Expression on Stem and Progenitor Cells of the Early Embryonic Nervous System
Author(s) -
SCHNEIDER A. S.,
ATLURI P.,
SHEN Q.,
BARNES W.,
MAH S. J.,
STADFELT D.,
GODERIE S. K.,
TEMPLE S.,
FLECK M. W.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04447.x
Subject(s) - acetylcholine receptor , embryonic stem cell , nicotinic agonist , progenitor cell , acetylcholine , neuroscience , biology , receptor , microbiology and biotechnology , nicotinic acetylcholine receptor , stem cell , ganglion type nicotinic receptor , endocrinology , biochemistry , gene
A bstract : Although the adult brain contains nicotinic acetylcholine (ACh) receptors vital to cortical function, little is known about the assembly of embryonic receptor subunits into functional receptors or their role in fetal brain development. We now report the first evidence of functional nicotinic ACh receptors on stem and progenitor cells of fetal mouse cerebral cortex as early as embryonic day 10.