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Proteolytic Processing of Chromogranins Is Modified in Brains of Transgenic Mice
Author(s) -
LASLOP ANDREA,
BECKER ALEXANDRA,
LINDBERG IRIS,
FISCHERCOLBRIE REINER
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04432.x
Subject(s) - genetically modified mouse , transgene , microbiology and biotechnology , chemistry , biology , biochemistry , gene
A bstract : In normal brain, secretogranin II and chromogranins A and S are extensively converted by endopeptidases to the peptides secretoneurin, GE‐19, and PE‐11, respectively. After genetic knockout of PC2 or its helper protein 7B2, but not after mutation of carboxypeptidase E, endoproteolytic processing decreased, as indicated by appearance of intermediate‐sized processing products.