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Molecular Biology of the Chromaffin Cell
Author(s) -
TRIFARÓ JOSÉMARÍA
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04427.x
Subject(s) - chromogranin a , promoter , chromaffin cell , gene , biology , gene isoform , catecholamine , transcription factor , microbiology and biotechnology , adrenal medulla , gene expression , genetics , endocrinology , immunology , immunohistochemistry
A bstract : A large number of molecular biology studies have been performed on chromaffin cells, and many genes involved in catecholamine synthesis, storage, and release have been cloned and their function determined. Catecholamine synthesis takes place in different cellular compartments, and enzymes involved in this process are subject to a fine regulation, as demonstrated by recent studies on their gene promoters. Genes coding for such intravesicular proteins as chromogranin A, B, and secretogranin II (chromogranin C) are also regulated in response to a variety of stimuli. Chromogranin gene promoters and transcription factors involved in their regulation have been elucidated. This review serves as an introduction to the studies described in the chapters to follow.