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Genomic Medicine
Author(s) -
ALESCI SALVATORE,
CHROUSOS GEORGE P.,
PACAK KAREL
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04424.x
Subject(s) - endocrine system , disease , bioinformatics , medicine , adrenal gland , gene transfer , endocrine disease , genomic medicine , genetic enhancement , computational biology , biology , gene , pathology , genetics , hormone
A bstract : Recent improvements in defining the molecular basis of disease have encouraged scientists worldwide to develop new therapeutic strategies based on engineered genes and cells. Genomic medicine has the potential to revolutionize diagnosis and therapy of a variety of human diseases, including endocrine disorders. Hypertension is the presenting feature of some of these disorders, such as congenital adrenal diseases, and adrenal and pituitary tumors. Preclinical data indicate that gene transfer to both the adrenal gland and the pituitary is not only feasible but also quite efficient. Research in this field is only in its infancy, but with the ever‐increasing advances in DNA technologies, genomic therapies for endocrine hypertension may become available within the next few decades.