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Protein Kinase A and Chromosomal Stability
Author(s) -
MATYAKHINA LUDMILA,
LENHERR SARA M.,
STRATAKIS CONSTANTINE A.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04333.x
Subject(s) - chromosome instability , biology , centrosome , carcinogenesis , kinase , genome instability , microbiology and biotechnology , protein kinase a , cell cycle , anaphase , cell division , chromosome segregation , genetics , cell , chromosome , cancer , dna damage , gene , dna
A bstract : All malignant human tumors contain chromosomal rearrangements. Among them, the majority of solid tumors show chromosomal instability, caused by abberations in chromosomal segregation during cell division. Chromosomal instability, defined as increased probability of formation of novel chromosomal mutations compared to that of normal or control cells, appears to be a feature of tumorigenesis in vivo and in vitro (in cancer cell lines). Several enzymatic kinases are involved in maintaining proper chromosomal segregation and regulating cell cycle progression. One such kinase, cAMP‐dependent protein kinase A (PKA), has a functional role in many aspects of cell signaling, metabolism, and proliferation. In this review, we will discuss the potential participation of PKA in chromosomal stability. This role includes the association of PKA with the centrosome, microtubules, and the anaphase‐promoting complex/cyclosome (ACP/C), all key aspects of proper chromosomal segregation.