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Cyclic AMP and the Reverse Transformation Reaction
Author(s) -
PUCK THEODORE T.,
WEBB PATRICIA,
JOHNSON ROBERT
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04331.x
Subject(s) - transformation (genetics) , cancer cell , cancer , process (computing) , cancer research , medicine , chemistry , computer science , biochemistry , gene , operating system
A bstract : Traditional methods for cancer treatment have been aimed at killing the cancer cells. Unfortunately this approach all too often is accompanied by harmful killing of normal cells. The present paper describes an experimental program in our laboratory in which cancer cells are treated so as to revert to normal cell behavior. This process, which we have named reverse transformation , appears to offer considerable hope in the treatment of a large number of malignancies.