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Uncoupling Proteins, Leptin, and Obesity
Author(s) -
GIACOBINO JEANPAUL
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04295.x
Subject(s) - ucp3 , leptin , thermogenin , brown adipose tissue , adipose tissue , white adipose tissue , uncoupling protein , endocrinology , medicine , thermogenesis , prdm16 , in vivo , adipokine , chemistry , ex vivo , microbiology and biotechnology , in vitro , obesity , biology , biochemistry
A bstract : The hypothesis that the novel uncoupling protein UCP3 is thermogenic and/or thermoregulatory is discussed. In vitro , ex vivo , and in vivo models are presented. The β 3 ‐adrenoceptors are crucial for the appearance of UCP1‐expressing cells in the white adipose tissue. These cells might differ from classical brown adipocytes. Besides its well‐known effect on brown adipose tissue UCP1, leptin might stimulate indirectly muscle UCP3 expression.