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Positional Cloning of an Obesity/Diabetes Susceptibility Gene(s) on Chromosome 11 in Pima Indians
Author(s) -
BAIER LESLIE,
KOVACS PETER,
WIEDRICH CHRISTOPHER,
CRAY KIMBERLY,
SCHEMIDT AMY,
SHEN GONGQING,
SUTHERLAND JEFFREY,
THUILLEZ PAMELA,
MULLER YUNHUA LI,
TRAURIG MICHAEL,
BOGARDUS CLIFTON
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04281.x
Subject(s) - genetics , single nucleotide polymorphism , linkage disequilibrium , locus (genetics) , biology , positional cloning , genetic linkage , haplotype , chromosome , gene , genotype
A bstract : Prior results from our genomic scan in Pima Indians indicated an obesity locus in a region on chromosome 11q23‐24 that was also linked to diabetes. Bivariate linkage analysis for the combined phenotype “diabesity” gave the strongest evidence for linkage (LOD = 5.2). Our aim is to positionally clone the gene(s) responsible for the linkage. Linkage disequilibrium mapping is being used to narrow the chromosomal region. Single nucleotide polymorphisms (SNPs) are being systematically identified and genotyped at 50‐kb intervals across the region of linkage. To date, 455 SNPs have been genotyped in 1229 Pimas. A region containing a cluster of SNPs strongly associated with BMI and a second region, approximately 2 Mb telomeric, containing a cluster of SNPs associated with diabetes have been preliminarily identified.