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Influence of Cytokines and Growth Factors on Distinct Steroidogenic Enzymes in Vitro
Author(s) -
HERRMANN M.,
SCHÖLMERICH J.,
STRAUB R. H.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04213.x
Subject(s) - aromatase , cholesterol side chain cleavage enzyme , enzyme , steroidogenic acute regulatory protein , endocrinology , sulfatase , chemistry , medicine , biology , biochemistry , gene expression , cytochrome p450 , gene , cancer , breast cancer
A bstract : Cytokines (IL‐1, IL‐6, IL‐8, IL‐11, TNF, IFN‐γ, and TGF‐β) and growth factors (EGF, bFGF, aFGF, and KGF) play an important role in modulation of hormone secretion by directly influencing specific enzyme steps of steroidogenesis in various endocrine cell types. For this tabular data collection, the following enzyme steps were considered: steroidogenic acute regulatory protein (StAR), side chain cleavage enzyme (P450scc), 3 beta‐hydroxysteroid dehydrogenase, 17‐alpha‐hydroxylase/17,20‐lyase (P450c17), 17‐beta‐hydroxysteroid‐dehydrogenase, aromatase complex, 5‐alpha‐reductase, P450c21, DHEAS sulfatase, and DHEA sulfotransferase. This collection summarizes the current information on how the mentioned cytokines and growth factors influence particular enzyme steps.