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Prediction of Allergenicity of Gene‐Modified Foods by Serum‐Based Testing
Author(s) -
POULSEN LARS K.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04143.x
Subject(s) - inhalation , allergen , placebo , food allergens , medicine , immunoglobulin e , immunology , allergy , pharmacology , anesthesia , pathology , antibody , alternative medicine
A bstract : On the basis of applying the IFBC/ILSI decision tree in a number of cases, a refinement of the scheme is suggested. Large differences in allergenic potential may be obtained by altering the route of administration of an allergen. Because an inhalation allergen can induce symptoms at different threshold doses depending on whether it is introduced via the inhalation or oral route, we propose that double‐blind, placebo‐controlled food challenges be performed in all cases of inhalation allergens being present in foods. Even proteins never previously ingested may cause IgE binding and elicit clinically relevant symptoms.