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Molecular Genetics of Acute Myeloid Leukemia
Author(s) -
BERNASCONI PAOLO,
BONI MARINA,
CAVIGLIANO PAOLA MARIA,
CALATRONI SILVIA,
GIARDINI ILARIA,
ROCCA BARBARA,
CARESANA MARILENA
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04121.x
Subject(s) - myeloid leukemia , biology , leukemia , polymerase chain reaction , fluorescence in situ hybridization , gene , pathogenesis , cancer research , haematopoiesis , acute leukemia , reverse transcriptase , genetics , chromosome , immunology , stem cell
A bstract : Recurring chromosomal abnormalities are detected in most patients with acute myeloid leukemia (AML). They may be associated with a distinct AML FAB subtype or may identify distinct clinicobiological entities within the same FAB subtype. Therefore, cytogenetic investigation has a pivotal role in AML diagnosis. In addition, it is one of the most valuable prognostic determinants of the disease, as recently demonstrated. The development of new molecular techniques, such as reverse transcriptase polymerase chain reaction and fluorescence in situ hybridization, has allowed perfect definition of the chromosome regions containing genes with a crucial role in normal hemopoiesis and leukemia. Understanding the action of such genes provides new insights into AML pathogenesis and has led us to envisage new therapeutic options.