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A Chemical Perspective on the Interplay Between NO, Reactive Oxygen Species, and Reactive Nitrogen Oxide Species
Author(s) -
ESPEY MICHAEL G.,
MIRANDA KATRINA M.,
THOMAS DOUGLAS D.,
XAVIER SANDHYA,
CITRIN DEBORAH,
VITEK MICHAEL P.,
WINK DAVID A.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04068.x
Subject(s) - reactive nitrogen species , nitric oxide , reactive oxygen species , chemistry , nitration , nitrogen oxide , nitrogen oxides , oxygen , nitrosation , nitrogen , sequela , oxide , biochemistry , nox , organic chemistry , medicine , psychiatry , waste management , engineering , combustion
A bstract : Nitric oxide (nitrogen monoxide, NO) plays a veritable cornucopia of regulatory roles in normal physiology. In contrast, NO has also been implicated in the etiology and sequela of numerous neurodegenerative diseases that involve reactive oxygen species (ROS) and nitrogen oxide species (RNOS). In this setting, NO is often viewed solely as pathogenic; however, the chemistry of NO can also be a significant factor in lessening injury mediated by both ROS and RNOS. The relationship between NO and oxidation, nitrosation, and nitration reactions is summarized. The salient factors that determine whether NO promotes, abates, or interconnects these chemistries are emphasized. From this perspective of NO chemistry, the type, magnitude, location, and duration of either ROS or RNOS reactions may be predicted.