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Nitric Oxide Transport and Storage in the Cardiovascular System
Author(s) -
MULLER BERNARD,
KLESCHYOV ANDREI L.,
ALENCAR JACICARLOS L.,
VANIN ANATOLY,
STOCLET JEANCLAUDE
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04063.x
Subject(s) - nitric oxide , chemistry , nitric oxide synthase , biophysics , hemoglobin , endothelium , nitrite , biochemistry , microbiology and biotechnology , biology , medicine , nitrate , organic chemistry
A bstract : Despite short halflife in biological fluids, nitric oxide (NO) can produce remote or long lasting effect in the cardiovascular system. Long distance transport or local storage of NO might explain these effects. In blood, recent findings suggest that in addition to being a major consumption pathway, interaction of NO with hemoglobin may permit O 2 ‐governed transport of NO (as S ‐nitrosohemoglobin) to tissues in which NO may be released together with O 2 , via transnitrosation of a transport protein. In blood vessels, two different putative NO stores have been characterized. The first is the photosensitive store, formed from endothelium‐derived NO. The mechanism of NO release from this store in the body (in absence of light) and its physiological relevance are unknown. The second store is generated in conditions of high tissue NO levels, as a consequence of the inducible NO synthase activity or in various stress conditions. This NO store involves formation of protein‐bound dinitrosyl iron complexes or S ‐nitrosated proteins, or both. Low molecular weight thiols can displace NO from these stores and probably transfer it to target membrane protein(s) such as K + channels, via transnitrosation reactions. These stores may be involved in defence mechanisms against inflammation or stress. Thus, NO transport and storage mechanisms may be implicated in a variety of NO effects. The mechanisms of their formation and of NO release and their physiologic and pathophysiologic relevance deserve further investigations.