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Vascular Assembly in Natural and Engineered Tissues
Author(s) -
HIRSCHI KAREN K.,
SKALAK THOMAS C.,
PEIRCE SHAYN M.,
LITTLE CHARLES D.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb03090.x
Subject(s) - paracrine signalling , biology , autocrine signalling , microbiology and biotechnology , blood vessel , progenitor cell , process (computing) , computational biology , gene , neuroscience , ex vivo , effector , in vivo , receptor , stem cell , genetics , computer science , endocrinology , operating system
A bstract : With the advent of molecular embryology and exploitation of genetic models systems, many genes necessary for normal blood vessel formation during early development have been identified. These genes include soluble effectors and their receptors, as well as components of cell‐cell junctions and mediators of cell‐matrix interactions. In vitro model systems (2‐D and 3‐D) to study paracrine and autocrine interactions of vascular cells and their progenitors have also been created. These systems are being combined to study the behavior of genetically altered cells to dissect and define the cellular role(s) of specific genes and gene families in directing the migration, proliferation, and differentiation needed for blood vessel assembly. It is clear that a complex spatial and temporal interplay of signals, including both genetic and environmental, modulates the assembly process. The development of real‐time imaging and image analysis will enable us to gain further insights into this process. Collaborative efforts among vascular biologists, biomedical engineers, mathematicians, and physicists will allow us to bridge the gap between understanding vessel assembly in vivo and assembling vessels ex vivo .