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Accelerated and Improved Osteointegration of Implants Biocoated with Bone Morphogenetic Protein 2 (BMP‐2)
Author(s) -
JENNISSEN HERBERT P.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb03067.x
Subject(s) - osseointegration , bone morphogenetic protein , bone morphogenetic protein 2 , titanium , bone morphogenetic protein 7 , biomedical engineering , chemistry , bone morphogenetic protein 6 , dentistry , microbiology and biotechnology , implant , medicine , biology , biochemistry , surgery , in vitro , organic chemistry , gene
A bstract : A concept and methodology are presented for the direct biocoating of implantable metals like titanium and stainless steel with bone morphogenetic protein 2 (BMP‐2) for future applications as cementless bone or dental prostheses. Such bioactive surfaces can influence cells and tissues by chemotactic as well as juxtacrine mechanisms. Reference is made to first experiments in sheep and rabbits in which BMP‐2 coatings impressively increased the osteoinductive potential of titanium implants.