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Emerging Design Principles in Biomaterials and Scaffolds for Tissue Engineering
Author(s) -
GRIFFITH LINDA G.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb03056.x
Subject(s) - tissue engineering , nanotechnology , regenerative medicine , regeneration (biology) , biochemical engineering , materials science , computer science , biomedical engineering , chemistry , cell , engineering , microbiology and biotechnology , biology , biochemistry
A bstract : Biomaterials and scaffolds play an essential role in tissue engineering by guiding new tissue growth in vivo and in vitro . While adaptation of existing surgical materials has fulfilled some needs in the field, new applications demand better control of bulk properties such as degradation and of surface properties that control cell interactions. Advances in molecular cell biology are driving the incorporation of new biological moieties into materials, and a set of design principles based on quantitative analysis of key cellular processes involved in regeneration is emerging. At the same time, new materials‐processing methodologies are emerging to allow fabrication of these fragile materials into devices appropriate for delivery.