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Therapeutic Potential of Implanted Tissue‐Engineered Bioartificial Muscles Delivering Recombinant Proteins to the Sheep Heart
Author(s) -
LU Y.,
SHANSKY J.,
TATTO M.,
FERLAND P.,
MCGUIRE S.,
MARSZALKOWSKI J.,
MAISH M.,
HOPKINS R.,
WANG X.,
KOSNIK P.,
NACKMAN M.,
LEE A.,
CRESWICK B.,
VANDENBURGH H.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb03055.x
Subject(s) - recombinant dna , tissue engineering , genetically engineered , chemistry , microbiology and biotechnology , biomedical engineering , biology , biochemistry , medicine , gene
A bstract : Tissue‐engineered primary adult sheep muscle cells genetically engineered to express either rhVEGF or rhIGF‐1 secreted the bioactive proteins locally in the sheep heart for at least 30 days.