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HLA‐DRB1, DQB1, and DQA1 Allele Profile in Brazilian Patients with Type 1 Diabetes Mellitus
Author(s) -
FERNANDES A. P. M.,
LOUZADAJÚNIOR P.,
FOSS M. C.,
DONADI E. A.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb02992.x
Subject(s) - allele , human leukocyte antigen , hla dqb1 , type 1 diabetes , diabetes mellitus , medicine , genetics , population , biology , antigen , gene , endocrinology , environmental health
A bstract : HLA class II profile was evaluated in 64 Brazilian patients presenting with type 1 diabetes mellitus. Although the Brazilian population is highly miscegenated, HLA‐DRB1*301, DRB1*04, DQB1*0302, and DQB1*0201 alleles, which are associated with the development of type 1 diabetes in several Western populations, were also overrepresented in Brazilian patients. In addition to HLA‐DRB1*15 and DQB1*0602 alleles, DRB1*11, DRB1*13, and DQA1*01 allele groups were associated with protection against the development of type 1 diabetes in Brazilian patients.