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Autoantibodies and HLA Susceptibility Markers in Canadian First‐Degree Relatives of Patients with Type 1 Diabetes
Author(s) -
BEHME M. T.,
MAHON J. L.,
DUPRÉ J.
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb02975.x
Subject(s) - autoantibody , glutamate decarboxylase , type 1 diabetes , human leukocyte antigen , first degree relatives , islet , immunology , medicine , diabetes mellitus , endocrinology , antibody , biology , antigen , enzyme , biochemistry , family history
A bstract : We examined the frequencies of autoantibodies to glutamate decarboxylase, GAD65, protein tyrosine phosphatase, IA‐2/ICA512, and insulin, and of HLA class II markers in ICA‐positive first‐degree relatives of patients with type 1 diabetes. Our results indicate that while the presence of HLA susceptibility markers is associated with anti‐islet autoantibodies, protective DQB1 markers do not absolutely prevent development of autoantibodies or progression to autoimmune diabetes.