Premium
Fas Stimulation Results in Selective Islet Infiltrate Apoptosis in Situ and Reversal of Diabetes
Author(s) -
DHARNIDHARKA VIKAS R.,
PATTEN YANCY VAN,
BAHJAT F. RENA,
CLARESALZLER MICHAEL
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb02960.x
Subject(s) - islet , stimulation , in situ , apoptosis , chemistry , diabetes mellitus , medicine , endocrinology , biochemistry , organic chemistry
A bstract : Breakdown of peripheral T cell regulation due to defective antigen‐activated apoptosis may lead to autoimmunity. In the nonobese diabetic (NOD) mouse model of type 1 diabetes mellitus, we have demonstrated defects in T cell activation and peripheral apoptosis. Stimulation of the Fas pathway by a Fas receptor agonist led to enhanced in vitro apoptosis and in vivo selective apoptosis of islet‐infiltrating lymphocytes. Administration of the Fas agonist immediately after onset of diabetes led to reversal of diabetes in NOD mice. Inducing peripheral T cell apoptosis may be a potential method for reversal of autoimmune diabetes.