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Corticosteroid‐Responsive Diabetes Mellitus Associated with Autoimmune Pancreatitis
Author(s) -
TANAKA SHOICHIRO,
KOBAYASHI TETSURO,
NAKANISHI KOJI,
OKUBO MINORU,
ODAWARA MASATO,
MURASE TOSHIO,
HASHIMOTO MASAJI,
WATANABE GORO,
MATSUSHITA HIROSHI,
INOKO HIDETOSHI,
TAKEUCHI KAZUO
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb02959.x
Subject(s) - autoimmune pancreatitis , diabetes mellitus , pancreatitis , medicine , autoimmune diabetes , corticosteroid , autoimmune disease , endocrinology , islet , disease
A bstract : Histopathological changes of biopsied pancreata were examined in three diabetic patients with autoimmune chronic pancreatitis (ACP). We found intra‐ and periinsular mononuclear cell (MNC)—mainly CD8 + T cell—infiltration as well as MNC infiltration around the ductal cells. Islet β cell volume decreased significantly. Some ductal cells expressed insulin and insulin promoter factor‐1 concomitantly in the affected pancreas. These findings provide new insight toward understanding the pathological mechanisms of corticosteroid treatment‐responsive diabetes associated with ACP.