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International Workshop on Lessons from Animal Models for Human Type 1 Diabetes
Author(s) -
BONIFACIO EZIO,
ATKINSON MARK,
EISENBARTH GEORGE,
SERREZE DAVID,
KAY THOMAS W. H.,
LEECHAN EDWIN,
SINGH BHAGIRATH
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb02941.x
Subject(s) - autoimmunity , autoantibody , nod , type 1 diabetes , immunology , animal model , diabetes mellitus , medicine , biology , computational biology , antibody , endocrinology
A bstract : The aim of this workshop was to identify autoantibody assays that could provide useful markers of autoimmunity in the NOD mouse model for type 1 diabetes. It was demonstrated that insulin autoantibodies measured by sensitive radiobinding assay are a marker of autoimmunity in NOD mice and draw into question the true nature of GADA and IA‐2A in this animal model.