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Implications of Protein Degradation in Aging
Author(s) -
Goto Sataro,
Takahashi Ryoya,
Kumiyama Atsushi,
Radák Zsolt,
Hayashi Toshiaki,
Takenouchi Masaki,
Abe Ryoichi
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb05635.x
Subject(s) - protein turnover , proteasome , protein degradation , organism , turnover , degradation (telecommunications) , ageing , microbiology and biotechnology , physiology , biology , chemistry , biochemistry , protein biosynthesis , genetics , telecommunications , management , computer science , economics
A bstract : Aging is characterized by accumulation of potentially harmful altered proteins that could lead to gradual deterioration of cellular functions and eventually result in increased probability of death. Metabolic turnover of proteins thus plays an essential role in maintaining the life of an organism. In this article we summarize our current knowledge on age‐related changes in protein turnover with special reference to degradation. Increase in half‐life of proteins with advancing age is well documented. Qualitative rather than quantitative changes of proteasomes appear to be responsible for this change. Dietary restriction and moderate long‐term exercise seem to restore higher proteasome activity and turnover rate of proteins in aged animals.