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Estrogen Replacement Therapy for the Potential Treatment or Prevention of Alzheimer's Disease
Author(s) -
MILLER MARILYN M.,
MONJAN ANDREW A.,
BUCKHOLTZ NEIL S.
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb04025.x
Subject(s) - estrogen , disease , neuroprotection , cognition , estrogen replacement therapy , medicine , cognitive decline , dementia , neuroscience , personality , estrogen therapy , psychology , bioinformatics , biology , social psychology
A bstract : Alzheimer's disease (AD) is an irreversible, progressive brain disorder that occurs gradually and results in memory loss, behavior and personality changes, and a decline in cognitive abilities. Although basic biological data suggest that estrogen may have neuroprotective and neuroenhancing functions, a number of studies have produced conflicting findings on the use of estrogen for maintaining cognitive function in older people. This review summarizes clinical studies that have examined the effects of estrogen in women with AD.