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Effects of Estrogen and Selective Estrogen Receptor Modulators on Hemostasis and Inflammation
Author(s) -
CUSHMAN MARY
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb04017.x
Subject(s) - raloxifene , tamoxifen , medicine , selective estrogen receptor modulator , hemostasis , estrogen , hormone replacement therapy (female to male) , myocardial infarction , estrogen receptor , inflammation , disease , bioinformatics , venous thromboembolism , oncology , breast cancer , cancer , thrombosis , biology , testosterone (patch)
A bstract : Postmenopausal hormone replacement therapy (HRT), tamoxifen, and raloxifene all share an increase of about three‐fold in the risk of venous thromboembolism (VTE). Currently, it is thought that HRT transiently increases the risk of myocardial infarction (MI), followed by subsequent reduction in risk, at least among women with established coronary heart disease. Raloxifene and tamoxifen are not known to share this apparent clinical effect. Study of hemostasis and inflammation factors, as surrogate end points, can be useful to form hypotheses concerning the pathophysiology related to clinical effects of these agents. Data presented here suggest differences among these agents that might relate to differences in clinical outcomes. From the vascular perspective, future studies need to focus on interactions of treatment with these biochemical parameters and their genetic correlates in order to define low‐ or high‐risk subgroups for intervention with these therapies.