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Developing Animal Models for Analyzing SERM Activity
Author(s) -
EMMEN JUDITH M. A.,
KORACH KENNETH S.
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb04000.x
Subject(s) - estrogen receptor , estrogen , selective estrogen receptor modulator , receptor , estrogen receptor beta , estrogen receptor alpha , medicine , endocrinology , biology , cancer , breast cancer
A bstract : Estrogens have effects on many organ systems, beyond the reproductive system, in both females and males. Estrogen effects are exerted through specific receptors, of which there are two types: estrogen receptor (ER) α and estrogen receptor (ER) β. To study the roles of each receptor in vivo , a series of mice were generated lacking either a functional ERα or ERβ or both. These mice, labeled αERKO, βERKO, or αβERKO, respectively, have been useful in defining the tissue specificities, localization, and functions of each of the estrogen receptors. These mouse models also show great promise for use in defining the effectiveness of putative SERMs.