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Nuclear Receptors, Coregulators, Ligands, and Selective Receptor Modulators
Author(s) -
McKENEIL J.,
O'MALLEY BERT W.
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03997.x
Subject(s) - receptor , chemistry , nuclear receptor , microbiology and biotechnology , biophysics , biology , transcription factor , biochemistry , gene
A bstract : Nuclear receptors are ligand‐inducible transcription factors that specifically regulate the expression of target genes involved in metabolism, development, and reproduction. Their primary function is to mediate the transcriptional response in target cells to hormones such as the sex steroids (progestins, estrogens, and androgens), adrenal steroids (glucocorticoids and mineralocorticoids), vitamin D 3 , and thyroid and retinoid (9‐ cis and all‐ trans ) hormones, in addition to a variety of other metabolic ligands. More than 100 nuclear receptors are known to exist and, together, these proteins comprise the single largest family of metazoan transcription factors, the nuclear receptor superfamily. Their natural ligands, as well as synthetic ligands (selective receptor modulators, or SRMs), are known to influence the interaction of these receptors with accessory molecules called coregulators .