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Remnant Lipoproteins and Atherogenesis
Author(s) -
KAWAKAMI AKIO,
YOSHIDA MASAYUKI,
TANAKA AKIRA,
NAKAJIMA KATSUYUKI,
YASUKOCHI YUKIO,
SHIMOKADO KENTARO,
NUMANO FUJIO
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03964.x
Subject(s) - chylomicron , lipoprotein , intermediate density lipoprotein , mechanism (biology) , chemistry , lipid metabolism , very low density lipoprotein , cholesterol , biochemistry , physics , quantum mechanics
A bstract : Remnant lipoproteins are reported to play a causative role in atherogenesis. They consist of chylomicron remnants and very low‐density lipoprotein remnants. They are heterogeneous in composition and metabolic pathway and are rapidly taken up from the circulation as soon as they are formed in normal lipid metabolism. These characteristics make it difficult to separate and subsequently analyze remnant lipoproteins. Recently, however, we developed a simple and reliable immunoseparation method to separate remnant lipoproteins, and the cellular mechanism(s) by which they contribute to atherogenesis have been elucidated.