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Enhanced Atherosclerosis in Lp(a) WHHL Transgenic Rabbits
Author(s) -
FAN JIANGLIN,
SUN HUIJUN,
UNOKI HIROYUKI,
SHIOMI MASAYUKI,
WATANABE TERUO
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03963.x
Subject(s) - apolipoprotein b , lipoprotein(a) , genetically modified mouse , lipoprotein , medicine , transgene , in vivo , lesion , endocrinology , cholesterol , familial hypercholesterolemia , risk factor , biology , pathology , biochemistry , microbiology and biotechnology , gene
A bstract : High lipoprotein(a) [Lp(a)] levels form a major risk factor for the development of atherosclerosis. The risk of elevated Lp(a) concentrations is significantly increased in patients who also have high levels of LDL cholesterol. Although the relation between Lp(a) and atherosclerosis has been reported in numerous studies, little is known about whether Lp(a) would exacerbate the complicated lesion formation in vivo . To test the hypothesis that increased plasma levels of Lp(a) may enhance the development of atherosclerosis in the setting of hypercholesterolemia, we generated WHHL transgenic rabbits expressing human apolipoprotein (a) and compared the atherosclerotic lesions with those of nontransgenic WHHL rabbits.