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Potential Role of Recombinant Annexin II in Diabetic Vascular Injury
Author(s) -
ISHII HIDETO,
YOSHIDA MASAYUKI,
HAJJAR KATHERINE A.,
TANAKA AKIRA,
YASUKOCHI YUKIO,
SHIMOKADO KENTARO,
NUMANO FUJIO
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03953.x
Subject(s) - plasmin , annexin a2 , annexin , recombinant dna , endothelium , hyperinsulinemia , medicine , endocrinology , plasminogen activator , diabetes mellitus , tissue plasminogen activator , receptor , activator (genetics) , chemistry , immunology , biochemistry , insulin resistance , enzyme , gene , flow cytometry
A bstract : Hyperinsulinemia and hyperglycemia have been associated with vascular injury such as atherosclerosis in diabetes mellitus. Recently, annexin II, a member of annexin family proteins, has been found to work as co‐receptor on endothelial cells for plasminogen and tissue plasminogen activator, facilitating plasmin generation on the surface of vascular endothelium. In this review, we overviewed the effect of glucose and insulin on plasmin generation in endothelial cells and its potential modulation by recombinant annexin II (rAN II) based on our data.