Premium Potential Role of Recombinant Annexin II in Diabetic Vascular InjuryPremium
Author(s)
ISHII HIDETO,
YOSHIDA MASAYUKI,
HAJJAR KATHERINE A.,
TANAKA AKIRA,
YASUKOCHI YUKIO,
SHIMOKADO KENTARO,
NUMANO FUJIO
Publication year2001
Publication title
annals of the new york academy of sciences
Resource typeJournals
PublisherBlackwell Publishing Ltd
A bstract : Hyperinsulinemia and hyperglycemia have been associated with vascular injury such as atherosclerosis in diabetes mellitus. Recently, annexin II, a member of annexin family proteins, has been found to work as co‐receptor on endothelial cells for plasminogen and tissue plasminogen activator, facilitating plasmin generation on the surface of vascular endothelium. In this review, we overviewed the effect of glucose and insulin on plasmin generation in endothelial cells and its potential modulation by recombinant annexin II (rAN II) based on our data.
Subject(s)activator (genetics) , annexin , annexin a2 , biochemistry , chemistry , diabetes mellitus , endocrinology , endothelium , enzyme , flow cytometry , gene , hyperinsulinemia , immunology , insulin resistance , medicine , plasmin , plasminogen activator , receptor , recombinant dna , tissue plasminogen activator
Language(s)English
SCImago Journal Rank1.712
H-Index248
eISSN1749-6632
pISSN0077-8923
DOI10.1111/j.1749-6632.2001.tb03953.x
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