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Role of Chemokine SDF‐1/PBSF and Its Receptor CXCR4 in Blood Vessel Development
Author(s) -
NAGASAWA TAKASHI
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03933.x
Subject(s) - microbiology and biotechnology , chemokine receptor , stromal cell , stromal cell derived factor 1 , chemokine , biology , chemokine receptor ccr5 , receptor , ccl21 , ccr1 , cxcr4 , cxcl16 , immunology , chemistry , cancer research , biochemistry
A bstract : Chemokines are a family of small, structurally related molecules that regulate cell trafficking. We isolated a chemokine, stromal cell‐derived factor/pre‐B cell growth‐stimulating factor (SDF‐1/PBSF), as a molecule that stimulates the growth of B lymphocyte precursors and then found its multiple physiological functions in development. SDF‐1/PBSF is essential for embryonic viability, B lymphopoiesis, bone marrow myelopoiesis, and cardiogenesis. Moreover, a primary physiologic receptor for SDF‐1/PBSF is a seven‐transmembrane G‐protein‐coupled receptor, CXCR4, that also functions as a coreceptor for strains of HIV‐1. In recent years, we have shown that SDF‐1/PBSF and CXCR4 chemokine ligand receptor system is required for vascularization of the gastrointestinal tract by analyzing mice deficient in these molecules, thus defining a new signaling system for organ vascularization during embryogenesis.