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Postradiation DNA Polymorphism
Author(s) -
SHERLINA SOPHIA S.,
VLADIMIROV VIKTOR G.
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03890.x
Subject(s) - dna , biology , malignant transformation , cancer , cancer research , immunology , genetics , microbiology and biotechnology
A bstract : The presence of DNA molecules with tumor‐specific genetic alterations has been demonstrated in the plasma of cancer patients. Such plasma DNA fragments may be immunogenic and provide immunologic support to the malignant cells. Further, the tumor‐specific plasma DNA may participate in the adaptive processes of the tumor cells in the cancer host. The mechanisms of the latter are unclear. However, from the standpoint of the resistance problem, understanding of DNA transformation after exposure of extreme factors is of great interest.