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Detection of Tumor‐Associated Circulating mRNA in Patients with Disseminated Malignant Melanoma
Author(s) -
RAPPL G.,
HASSELMANN D. O.,
RÖßLER M.,
UGUREL S.,
TILGEN W.,
REINHOLD U.
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03884.x
Subject(s) - melanoma , messenger rna , extracellular , rnase p , rna , peripheral blood , cancer research , medicine , immunology , pathology , biology , gene , microbiology and biotechnology , biochemistry
A bstract : It has been suggested that extracellular mRNA might be released from tumor cells and might be protected from serum RNase by proteins or proteolipid complexes. Our group has recently assessed the potential value of extracellular RNA detection by RT‐PCR in the peripheral blood of patients with metastatic melanoma.