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Detection of Fetal NRBCs in Maternal Blood of Pregnant Carriers of β‐Thalassemia Using Anti‐γ and Anti‐ε Monoclonal Antibodies
Author(s) -
MAVROU ARIADNI,
KOLIALEXI AGGELIKI,
ANTSAKLIS ARISTIDES,
KRIKOS XENOFON,
KORATZIS ASTERIS,
METAXOTOU CATHERINE
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03877.x
Subject(s) - fetus , fetal hemoglobin , nucleated red blood cell , thalassemia , pregnancy , prenatal diagnosis , medicine , monoclonal antibody , beta thalassemia , hemoglobin , embryonic stem cell , obstetrics , andrology , antibody , immunology , biology , genetics , gene
A bstract : Fetal nucleated red blood cells (NRBCs) entering maternal circulation during pregnancy constitute a potential source of material for safe and reliable noninvasive prenatal diagnosis. The increased prevalence of β‐thalassemia mutations in countries like Greece may create a problem, making it difficult to distinguish between NRBCs of fetal or maternal origin. Use of Ab against embryonic hemoglobin ε may increase specificity for fetal NRBC detection. In the present study, Ab against embryonic hemoglobin ε was used in the first and second trimesters of pregnancy in order to determine if specificity for fetal NRBC detection could be increased.