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Evaluating the Performance of a Hybrid Artificial Liver Support System With a Recoverable Hepatic Failure Rat Model
Author(s) -
IJIMA HIROYUKI,
NOGUCHI AYAKO,
KATSUNO TAKEYUKI,
ONO TSUTOMU,
NAKAZAWA KOHJI,
FUNATSU KAZUMORI,
KAWAKAMI KOEI
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03846.x
Subject(s) - artificial liver , liver failure , chemistry , computer science , medicine
A bstract : To evaluate the performance of an artificial liver, we created a recoverable hepatic failure rat model. This involves a 30–60 minute warm ischemia, via clamping, of one‐third of the liver with a partial (two‐thirds) hepatectomy. Variations on this method provide for the possibility of several modes of hepatic failure. Survival time of the rats was prolonged (35%) by applying our hybrid artificial liver. However, the extracorporeal circulation is a considerable burden to the rat. Therefore, we need to apply the hybrid artificial liver intermittently and repeatedly.