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Advances in Bioartificial Liver Assist Devices
Author(s) -
PATZER JOHN F.
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03844.x
Subject(s) - bioartificial liver device , xenotransplantation , liver failure , biocompatible material , medicine , biomedical engineering , preclinical testing , computer science , hepatocyte , surgery , transplantation , medical physics , chemistry , in vitro , biochemistry
A bstract : Rapid advances in development of bioartificial liver assist devices (BLADs) are exciting clinical interest in the application of BLAD technology for support of patients with acute liver failure. Four devices (Circe Biomedical HepatAssist ® , Vitagen ELAD ™ , Gerlach BELS, and Excorp Medical BLSS) that rely on hepatocytes cultured in hollow‐fiber membrane technology are currently in various stages of clinical evaluation. Several alternative approaches for culture and perfusion of hepatocytes have been evaluated in preclinical, large animal models of liver failure, or at a laboratory scale. Engineering design issues with respect to xenotransplantation, BLAD perfusion, hepatocyte functionality and culture maintenance, and ultimate distribution of a BLAD to a clinical site are delineated.