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The Role of a Bioengineered Artificial Kidney in Renal Failure
Author(s) -
FISSELL WILLIAM H.,
KIMBALL JASON,
MACKAY SHERRILL M.,
FUNKE ANGELA,
HUMES H. DAVID
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03841.x
Subject(s) - artificial kidney , erythropoietin , kidney , dialysis , medicine , transplantation , kidney disease , extracorporeal , endocrine system , intensive care medicine , endocrinology , hormone
A bstract : Renal failure continues to carry substantial burden of morbidity and mortality in both acute and chronic forms, despite advances in transplantation and dialysis. There is evidence to suggest that the kidney has metabolic, endocrine, and immune effects transcending its filtration functions, even beyond secretion of renin and erythropoietin. Our laboratory has developed experience in the tissue culture of renal parenchymal cells, and has now been able to demonstrate the metabolic activity of these cells in an extracorporeal circuit recapitulating glomerulotubular anatomy. We have observed active transport of sodium, glucose, and glutathione. We describe the design and initial preclinical testing of the bioartificial kidney, as well as future directions of our research.