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Newly Developed Aminopropyl‐Silicate Immunoisolation Membrane for a Microcapsule‐Shaped Bioartificial Pancreas
Author(s) -
SAKAI SHINJI,
ONO TSUTOMU,
IJIMA HIROYUKI,
KAWAKAMI KOEI
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03840.x
Subject(s) - membrane , silicate , chemical engineering , permeability (electromagnetism) , chemistry , molar ratio , materials science , polymer chemistry , biochemistry , organic chemistry , catalysis , engineering
A bstract : An aminopropyl‐silicate membrane, synthesized from tetramethoxysilane (TMOS) and 3‐aminopropyltrimethoxysilane (APTrMOS) by the sol‐gel method, was formed onto Ca‐alginate gel beads via electrostatic interactions. The permeability of the membrane could be controlled easily by changing the molar ratio of both the precursors ([APTrMOS]/[TMOS]). The aminopropyl‐silicate membrane prepared at a molar ratio of 2.40 rejected γ‐globulin and BSA successfully, whereas it permeated ovalbumin. This result indicates that the molecular weight cutoff point of this newly developed aminopropyl‐silicate membrane is approximately 60 kDa.