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Clinical Experience with a Surgical Approach to Hydrops
Author(s) -
NEELY J. GAIL
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03757.x
Subject(s) - medicine , retrospective cohort study , intervention (counseling) , vertigo , endolymphatic hydrops , cohort , disease , pediatrics , surgery , meniere's disease , psychiatry
A bstract : This work was based upon the need to look at the role of surgical intervention in cases of presumed hydrops encountered in usual medical practice. A retrospective cohort study of 292 consecutive cases diagnosed as Meniere's disease was used to identify subjects severely enough affected to elect surgical relief. Two nested case‐control design studies were subsequently conducted: one to compare surgical failures (4 cases) with successes (15 controls); and the other to compare the surgical group (19 cases) with a uniform random sample of all presenting Meniere's disease cases (10 controls). These data suggest the following testable hypotheses: (1) the younger the age of onset, the higher the probability that surgical intervention will be required to control episodic vertigo; (2) the younger the age of onset, the higher the probability of the failure of nondestructive surgery; and (3) patients destined for surgical intervention are likely to require at least twice as much office‐based medical care as the general group of presenting Meniere's patients. A biological question arising from these data is, Does age influence the putative homeostatic pathophysiology implicated in hydrops?