Premium
Stem Cell Transplantation across Major Genetic Barriers
Author(s) -
REISNER YAIR
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03600.x
Subject(s) - cytotoxic t cell , cd8 , immunology , fas ligand , haematopoiesis , progenitor cell , biology , stem cell , transplantation , population , hematopoietic stem cell transplantation , cancer research , immune system , microbiology and biotechnology , in vitro , apoptosis , medicine , programmed cell death , genetics , environmental health
A bstract : Megadose haploidentical transplants, mismatched at three HLA loci, engraft rapidly and durably without induction of graft‐versus‐host disease (GVHD). In vitro studies suggest that veto cells, contained in the population of hematopoietic progenitors, facilitate this favorable outcome. Cytotoxic T cells, not reactive against the recipient but reactive against a third party, are potent veto cells and can synergize with the stem cells and facilitate allogeneic bone marrow engraftment without GVHD. Experiments with mice deficient in FasL and Fas, with transfer of FasL gene and with anti‐CD8 antibody, suggest that the veto activity associated with cytotoxic T lymphocytes (CTLs) requires simultaneous expression of FasL and CD8.