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Neurokinin‐1 Receptor Antagonists Block Acute Cocaine‐Induced Horizontal Locomotion
Author(s) -
KRAFT MADELYNE,
AHLUWAHLIA SONIA,
ANGULO JESUS A.
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03562.x
Subject(s) - block (permutation group theory) , tachykinin receptor 1 , receptor , pharmacology , neuroscience , medicine , chemistry , psychology , substance p , neuropeptide , mathematics , geometry
A bstract : Systemic exposure to neurokinin‐1 receptor antagonists CP099994 or LY306740 prior to cocaine administration (10 mg/kg i.p.) blocks acute, cocaine‐induced horizontal locomotion. CP099994 (30 mg/kg) was delivered i.p. 30 minutes before cocaine exposure, and LY306740 (5 mg/kg) was delivered continuously by osmotic minipump for 12–14 hours before cocaine administration. These results suggest that endogenous substance P acting via neurokinin‐1 receptors is necessary for the expression of acute cocaine‐induced hyperactivity.