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Factor XIII Prevents Development of Myocardial Edema in Children Undergoing Surgery for Congenital Heart Disease
Author(s) -
WOZNIAK GERNOLD,
NOLL THOMAS,
AKINTÜRK HAKAN,
THUL JOSEF,
MÜLLER MATTHIAS
Publication year - 2001
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2001.tb03549.x
Subject(s) - medicine , perioperative , edema , extracorporeal circulation , factor xiii , surgery , heart failure , cardiac surgery , heart disease , anesthesia , cardiology , fibrinogen
A bstract : In a prospective investigation of perioperative cardiac edema formation requiring a delayed sternal closure, we identified thrombin increase combined with a simultaneous decrease of factor XIII as a probable cause. After experimental studies additionally revealed that factor XIII could protect endothelial barrier function, we did another prospective randomized trial in which factor XIII or placebo was preoperatively substituted. The substitution finally showed distinct effects minimizing the incidence of myocardial swelling. Therefore, the clinical application of factor XIII may have a valuable therapeutic benefit in cases of leakage syndrome during extracorporeal circulation in congenital heart surgery.